Over the past two days, WHO convened more than 15 countries and over 20 regional health agencies, health emergency networks and other partners to test, for the first time, a new global coordination mechanism for health emergencies.
The two-day simulation, Exercise Polaris, tested WHO’s Global Health Emergency Corps (GHEC), a framework designed to strengthen countries’ emergency workforce, coordinate the deployment of surge teams and experts, and enhance collaboration between countries.
The exercise simulated an outbreak of a fictional virus spreading across the world.
Participating countries included Canada, Colombia, Costa Rica, Denmark, Ethiopia, Germany, Iraq, Kingdom of Saudi Arabia, Mozambique, Nepal, Pakistan, Qatar, Somalia Uganda and Ukraine, with additional countries as observers. Each country participated through its national health emergency coordination structure and worked under real-life conditions to share information, align policies and activate their response.
Regional and global health agencies and organizations, including Africa CDC, European CDC, IFRC, IOM, UNICEF and established emergency networks such as the Global Outbreak Alert and Response Network, the Emergency Medical Teams initiative, Stand-by partners and the International Association of National Public Health Institutes, worked together to support country-led responses. More than 350 health emergency experts connected globally through this exercise.
“This exercise proves that when countries lead and partners connect, the world is better prepared,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “No country can face the next pandemic alone. Exercise Polaris shows that global cooperation is not only possible – it is essential.”
Throughout the simulation, countries led their own response efforts while engaging with WHO for coordination, technical guidance and emergency support. The exercise provided a rare opportunity for governments to test preparedness in a realistic environment, one where trust and mutual accountability were as critical as speed and capacity.
“The exercise sought to put into practice the procedures for inter-agency response to international health threats. Efficient coordination and interoperability processes are key to guaranteeing timely interventions in health emergencies,” said Dr Mariela Marín, Vice Minister of Health of Costa Rica, thanking the Pan American Health Organization for their support and the members of the National Risk Management System for their engagement.
“Polaris demonstrated the critical importance of cultivating trust before a crisis occurs,” said Dr Soha Albayat from Qatar. “The foundation of our collaborative efforts is significantly stronger than in years past. We've moved beyond reactive measures, and are now proactively anticipating, aligning, and coordinating our cross-border emergency response plans.”
“The Global Health Emergency Corps has evolved into a powerful platform, building on practice, trust and connection,” said Dr Mike Ryan, Executive Director of WHO’s Health Emergencies Programme. “Exercise Polaris showed what is possible when countries operate with urgency and unity supported by well-connected partners. It is a strong signal that we are collectively more ready than we were.”
At a time when multilateralism is under pressure and preparedness is often framed through a national lens, Exercise Polaris reaffirmed that health is a global issue.
The World Health Organization (WHO) today launched new guidance to help all countries reform and strengthen mental health policies and systems. Mental health services worldwide remain underfunded, with major gaps in access and quality. In some countries, up to 90% of people with severe mental health conditions receive no care at all, while many existing services rely on outdated institutional models that fail to meet international human rights standards.
The guidance provides a clear framework to transform mental health services in line with the latest evidence and international human rights standards, ensuring quality care is accessible to all.
"Despite rising demand, quality mental health services remain out of reach for many people," said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. "This new guidance gives all governments the tools to promote and protect mental health and build systems that serve everyone.”
While effective prevention and treatment interventions exist, most people living with mental health conditions do not have access to these. The new WHO guidance sets out concrete actions to help countries close these gaps and ensure mental health is promoted and protected, with a focus on:
The guidance identifies five key policy areas requiring urgent reform: leadership and governance, service organization, workforce development, person-centred interventions, and addressing social and structural determinants of mental health.
The WHO guidance serves as a critical tool for governments, policymakers, and stakeholders working to strengthen mental health systems and improve access to mental health care.
By offering a menu of policy directives, strategies and actions to guide reform efforts, the guidance supports policy makers to prioritize and tailor policies to their specific national context, in line with their available resources and operational structures.
"This new WHO guidance provides practical strategies for countries to build inclusive, responsive and resilient mental health systems. Designed to be flexible, it allows all countries – whether low- middle- or high-income - to adapt their approach to mental health care based on national context, needs, and priorities,” said Dr Michelle Funk, Unit Head, Policy, Law and Human Rights in the WHO Department for Mental Health and Substance Abuse.
The guidance was developed in consultation with global experts, policymakers and individuals with lived experience. The policy guidance also builds on the resources, guidance and tools developed under the WHO QualityRights initiative, aiming to promote a person-centred, recovery-oriented and rights-based approach to mental health. WHO will support countries in implementing the guidance through technical assistance and capacity-building initiatives.
The WHO Technical Advisory Group on COVID-19 Vaccine Composition (TAG-CO-VAC) continues to closely monitor the genetic and antigenic evolution of SARS-CoV-2 variants, immune responses to SARS-CoV-2 infection and COVID-19 vaccination, and the performance of COVID-19 vaccines against circulating variants. Based on these evaluations, WHO advises vaccine manufacturers and regulatory authorities on the implications for future updates to COVID-19 vaccine antigen composition. The next decision-making meeting of the TAG-CO-VAC is scheduled for May 2025, after which a statement on COVID-19 vaccine antigen composition and an accompanying data annex will be published on the WHO website. These meetings are timed to balance the availability of the latest epidemiological, immunological, and virological data, with the kinetics of vaccine-induced protection and the lead time manufacturers need to update the antigen composition of authorized COVID-19 vaccines.
The purpose of this statement is to guide the scientific community and vaccine manufacturers as to which data should be generated ahead of the May 2025 TAG-CO-VAC deliberations. It is an update to the previous statement on the types of data requested in October 2024.1
To inform decisions on COVID-19 vaccine antigen composition,2-6 the TAG-CO-VAC reviews data (see Table) on the genetic evolution of SARS-CoV-2 and the antigenic characteristics of previously and currently circulating variants. This includes the analysis of animal antisera following primary infection or vaccination in one-way and two-way neutralization tests, as well as immunogenicity data that assess the breadth and durability of immune responses, including neutralizing antibody responses, using sera from sequentially immunized or infected animals and pre-and post-vaccination human sera. The TAG-CO-VAC also considers vaccine effectiveness (VE) estimates of currently approved COVID-19 vaccines, particularly those that control for time since vaccination and that provide variant-specific estimates across different vaccine platforms for protection against any infection, symptomatic disease, and severe disease. Further examples of published data reviewed by TAG-CO-VAC and used to inform decisions on COVID-19 vaccine antigen composition can be found in the annexes accompanying each of the previous statements.2-6
In addition, the TAG-CO-VAC reviews available data from vaccine manufacturers, including animal and human studies demonstrating the breadth and durability of immune responses elicited by currently authorized vaccines, as well as any vaccine candidates in development. For vaccine candidates in development, the TAG-CO-VAC highlights the utility of clinical immunogenicity data for decision-making on COVID-19 vaccine antigen composition. The TAG-CO-VAC also notes that comparable immunogenicity data (i.e. to the same variants) from previous vaccine compositions are especially useful. Vaccine manufacturers are also asked to provide observational epidemiological data that demonstrate the efficacy or effectiveness of their authorized COVID-19 vaccines, as well as any vaccine candidates in development.
At this stage, the key antisera and antigens of interest for the May 2025 decision-making meeting for demonstrating breadth include antisera to: BA.2 (other historical reference viruses – e.g., index virus, Alpha, BA.1 – are also useful for determining antigenic relationships), XBB.1.5, JN.1, KP.2, XEC, LP.8.1, LF.7.2 and potentially emerging SARS-CoV-2 variants. Antisera of interest are animal sera after single or sequential exposure and human sera after a boost with monovalent JN.1, KP.2 or XBB.1.5 vaccines. Both pre- and post-vaccination sera should be included and, for all antisera, neutralizing antibody titers should be analyzed against at least one variant that emerged after the vaccine antigen, where feasible. Analysis of these antisera against the same panel of virus antigens as well as other new emerging SARS-CoV-2 variants will provide insight into antigenic characteristics of previous and emerging variants. Emerging variants include the list of SARS-CoV-2 Variants of Interest (VOI) and Variants Under Monitoring (VUM) maintained on the WHO website. Relative VE estimates should be calculated during periods of circulation of XBB, JN.1, KP.3.1.1, XEC or other emerging variant(s) in human populations across age groups, with separate VE estimates for each of the following vaccine antigen compositions: monovalent JN.1, monovalent KP.2 or monovalent XBB.1.5. Where available, the underlying rates of disease outcomes used to derive the relative VE estimates should also be provided.
In preparation for the May 2025 meeting, the TAG-CO-VAC encourages the scientific community and vaccine manufacturers to prioritize generating and sharing the data outlined in the Table below to ensure evidence-informed deliberations on COVID-19 vaccine antigen composition; please contact the TAG-CO-VAC Secretariat: [tagcovac@who.int].
| Type of data | Comments |
|---|---|
| SARS-CoV-2 genetic evolution | Key variants include the list of Variants of Interest (VOI) and Variants Under Monitoring (VUM). This list is maintained on the WHO website.+ |
| Antigenic characterization of previous and emerging SARS-CoV-2 variants | Animal sera following primary infection or vaccination against each of the following variants: BA.2, XBB.1.5, JN.1, KP.2, XEC, LP.8.1, LF.7.2 and potentially emerging variants* analyzed in one-way and two-way neutralization tests (pseudotype and live virus neutralization assays). |
| Preliminary immunogenicity data on breadth and durability of immune responses following vaccination or infection with SARS-CoV-2 variant antigens. | Neutralization of various representative viruses by non-naïve animal sera (e.g., sequentially immunized or infected), for each of the following antigens: BA.2, XBB.1.5, JN.1, KP.2, XEC, LP.8.1, LF.7.2 and emerging variants;* Neutralization of various representative viruses (BA.2, XBB.1.5, JN.1, KP.2, XEC, LP.8.1, LF.7.2 and potentially emerging variants*) by both pre- and post-vaccination human sera. Vaccinee sera should be analyzed in priority order: JN.1, KP.2, XBB.1.5; Neutralization of variants (BA.2, XBB.1.5, JN.1, KP.2, XEC, LP.8.1, LF.7.2 and potentially emerging variants*) by sera from cohorts that are representative of recent population immunity. |
| Vaccine effectiveness (VE) estimates of currently approved vaccines | Relative VE estimates during periods of circulation of XBB, JN.1, KP.3.1.1, XEC or emerging variant(s) * in human populations. Studies need to estimate relative VE by time since vaccination or at least provide a measure of time since vaccination, such as the mean or median. They should also provide variant-specific estimates and distinct estimates for each of the following vaccine antigen compositions across different vaccine platforms: monovalent JN.1, monovalent KP.2, or monovalent XBB.1.5. Studies should also provide relative VE for a range of outcomes beyond severe disease, including any infection or symptomatic disease. Severe disease should not be defined using generic hospital admission data, but rather with specific criteria such as oxygen use, ventilation, or admission to intensive care due to respiratory symptoms. Where available, underlying rates of disease outcomes used to estimate the relative VE should also be provided. |
| Data from vaccine manufacturers | Animal and human data that demonstrate the breadth and durability in immune responses elicited by vaccines in current portfolio, as well as any vaccine candidates in development, against BA.2, XBB.1.5, JN.1, KP.2, XEC, LP.8.1, LF.7.2 and potentially emerging variants;* Observational epidemiological data that demonstrate the efficacy or effectiveness of any vaccines in current portfolio, as well as any vaccine candidates in development, against BA.2, XBB.1.5, JN.1, KP.2, XEC, LP.8.1, LF.7.2 and potentially emerging variants.* |
+ WHO website: https://www.who.int/activities/tracking-SARS-CoV-2-variants
* Key emerging variants that evolve and considered relevant for demonstrating breadth include the list of Variants of Interest (VOI) and Variants Under Monitoring (VUM). This list is maintained on the WHO website: https://www.who.int/activities/tracking-SARS-CoV-2-variants
References
The number of children dying globally before their fifth birthday declined to 4.8 million in 2023, while stillbirths declined modestly, still remaining around 1.9 million, according to two new reports released today by the United Nations Inter-agency Group for Child Mortality Estimation (UN IGME).
Since 2000, child deaths have dropped by more than half and stillbirths by over a third, fuelled by sustained investments in child survival worldwide. In 2022, the world reached a historic milestone when child deaths dropped slightly below 5 million for the first time. However, progress has slowed and too many children are still being lost to preventable causes.
"Millions of children are alive today because of the global commitment to proven interventions, such as vaccines, nutrition, and access to safe water and basic sanitation,” said UNICEF Executive Director Catherine Russell. “Bringing preventable child deaths to a record low is a remarkable achievement. But without the right policy choices and adequate investment, we risk reversing these hard-earned gains, with millions more children dying from preventable causes. We cannot allow that to happen.”
Decades of progress in child survival are now at risk as major donors have announced or indicated significant funding cuts to aid ahead. Reduced global funding for life-saving child survival programmes is causing health-care worker shortages, clinic closures, vaccination programme disruptions, and a lack of essential supplies, such as malaria treatments. These cuts are severely impacting regions in humanitarian crises, debt-stricken countries, and areas with already high child mortality rates. Global funding cuts could also undermine monitoring and tracking efforts, making it harder to reach the most vulnerable children, the Inter-agency Group warned.
“From tackling malaria to preventing stillbirths and ensuring evidence-based care for the tiniest babies, we can make a difference for millions of families,” said Dr Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization. “In the face of global funding cuts, there is a need more than ever to step up collaboration to protect and improve children’s health.”
Even before the current funding crisis, the pace of progress on child survival had already slowed. Since 2015, the annual rate of reduction of under-five mortality has slowed by 42%, and stillbirth reduction has slowed by 53%, compared to 2000–2015.
Almost half of under-five deaths happen within the first month of life, mostly due to premature birth and complications during labour. Beyond the newborn period, infectious diseases, including acute respiratory infections such as pneumonia, malaria, and diarrhoea, are the leading causes of preventable child death. Meanwhile, 45% of late stillbirths occur during labour, often due to maternal infections, prolonged or obstructed labour, and lack of timely medical intervention.
Better access to quality maternal, newborn, and child health care at all levels of the health system will save many more lives, according to the reports. This includes promotive and preventive care in communities, timely visits to health facilities and health professionals at birth, high-quality antenatal and postnatal care, well-child preventive care such as routine vaccinations and comprehensive nutrition programmes, diagnosis and treatment for common childhood illnesses, and specialized care for small and sick newborns.
“Most preventable child deaths occur in low-income countries, where essential services, vaccines, and treatments are often inaccessible”, said Juan Pablo Uribe, World Bank Global Director for Health and Director of the Global Financing Facility. “Investing in children's health ensures their survival, education, and future contributions to the workforce. With strategic investments and strong political will, we can continue to reduce child mortality, unlocking economic growth and employment opportunities that benefit the entire world.”
The reports also show that where a child is born greatly influences their chances of survival. The risk of death before age five is 80 times higher in the highest-mortality country than the lowest-mortality country, for example, while a child born in sub-Saharan Africa is on average 18 times more likely to die before turning five than one born in Australia and New Zealand. Within countries, the poorest children, those living in rural areas, and those with less-educated mothers face the higher risks.
Stillbirth disparities are just as severe, with nearly 80% occurring in sub-Saharan Africa and Southern Asia, where women are six to eight times more likely to experience a stillbirth than women in Europe or North America. Meanwhile, women in low-income countries are eight times more likely to experience a stillbirth than those in high-income countries.
“Disparities in child mortality across and within nations remain one of the greatest challenges of our time,” said the UN DESA Under-Secretary-General, Li Junhua. “Reducing such differences is not just a moral imperative but also a fundamental step towards sustainable development and global equity. Every child deserves a fair chance at life, and it is our collective responsibility to ensure that no child is left behind.”
UN IGME members call on governments, donors, and partners across the private and public sectors to protect the hard-won gains in saving children’s lives and accelerate efforts. Increased investments, service integration, and innovations are urgently needed to scale up access to proven life-saving health, nutrition, and social protection services for children and pregnant mothers.
Notes to editors
The UN IGME child mortality report
The two reports – Levels & Trends in Child Mortality and Counting Every Stillbirth – are the first of a series of important global data sets released in 2025. UN maternal mortality figures will be published in the coming weeks.
About UN IGME
The United Nations Inter-agency Group for Child Mortality Estimation or UN IGME was formed in 2004 to share data on child mortality, improve methods for child mortality estimation, report on progress towards child survival goals and enhance the capacity of countries to produce timely and properly evaluated estimates of child mortality. UN IGME is led by UNICEF and includes the World Health Organization, the World Bank Group and the Population Division of the United Nations Department of Economic and Social Affairs.
For more information: http://www.childmortality.org/
On the occasion on World Tuberculosis (TB) Day, marked on 24 March, the World Health Organization (WHO) is calling for an urgent investment of resources to protect and maintain tuberculosis (TB) care and support services for people in need across regions and countries. TB remains the world’s deadliest infectious disease, responsible for over 1 million deaths annually bringing devastating impacts on families and communities.
Global efforts to combat TB have saved an estimated 79 million lives since 2000. However, the drastic and abrupt cuts in global health funding happening now are threatening to reverse these gains. Rising drug resistance especially across Europe and the ongoing conflicts across the Middle-East, Africa and Eastern Europe, are further exacerbating the situation for the most vulnerable.
Under the theme Yes! We Can End TB: Commit, Invest, Deliver, World Tuberculosis Day 2025 campaign highlights a rallying cry for urgency, and accountability and hope. “The huge gains the world has made against TB over the past 20 years are now at risk as cuts to funding start to disrupt access to services for prevention, screening, and treatment for people with TB,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “But we cannot give up on the concrete commitments that world leaders made at the UN General Assembly just 18 months ago to accelerate work to end TB. WHO is committed to working with all donors, partners and affected countries to mitigate the impact of funding cuts and find innovative solutions.”
Early reports to WHO reveal that severe disruptions in the TB response are seen across several of the highest-burden countries following the funding cuts. Countries in the WHO African Region are experiencing the greatest impact, followed by countries in the WHO South-East Asian and Western Pacific Regions. Twenty seven countries are facing crippling breakdowns in their TB response, with devastating consequences, such as:
Nine countries report failing TB drug procurement and supply chains, jeopardizing treatment continuity and patient outcomes.
The 2025 funding cuts further exacerbate an already existing underfunding for global TB response. In 2023, only 26% of the US$ 22 billion annually needed for TB prevention and care was available, leaving a massive shortfall. TB research is in crisis, receiving just one-fifth of the US$ 5 billion annual target in 2022 – severely delaying advancements in diagnostics, treatments, and vaccines. WHO is leading efforts to accelerate TB vaccine development through the TB Vaccine Accelerator Council, but progress remains at risk without urgent financial commitments.
In response to the urgent challenges threatening TB services worldwide, WHO’s Director-General and Civil Society Task Force on Tuberculosis have issued a decisive statement. The joint statement released this week, demands immediate, coordinated efforts from governments, global health leaders, donors, and policymakers to prevent further disruptions. The statement outlines five critical priorities:
“This urgent call is timely and underscores the necessity of swift, decisive action to sustain global TB progress and prevent setbacks that could cost lives,” said Dr Tereza Kasaeva, Director of WHO’s Global Programme on TB and Lung Health. “Investing in ending TB is not only a moral imperative but also an economic necessity – every dollar spent on prevention and treatment yields an estimated US$ 43 in economic returns.”
As one of the solutions to combating growing resource constraints, WHO is driving the integration of TB and lung health within primary healthcare as a sustainable solution. New technical guidance released by WHO outlines critical actions across the care continuum, focusing on prevention, early detection of TB and comorbidities, optimized management at first contact and improved patient follow-up. The guidance also promotes better use of existing health systems, addressing shared risk factors such as overcrowding, tobacco, undernutrition and environmental pollutants.
By tackling TB determinants alongside communicable and non-communicable diseases, lung conditions, and disabilities through a unified strategy, WHO aims to reinforce the global response and drive lasting improvements in health outcomes.
On World TB Day, WHO calls on everyone: individuals, communities, societies, donors and governments, to do their part to end TB. Without concerted action from all stakeholders, the TB response will be decimated, reversing decades of progress, putting millions of lives at risk and threatening health security.
On 24 March 2025, a correction was made to the second sentence in the first paragraph of this news release as noted below.
The sentence in the original news release read:
TB remains the world’s deadliest infectious disease, responsible for over 1 million people annually bringing devastating impacts on families and communities.
This was changed to:
TB remains the world’s deadliest infectious disease, responsible for over 1 million deaths annually bringing devastating impacts on families and communities.
Today, during the annual Partnership for Healthy Cities Summit in Paris, three cities were recognized for their achievements in preventing noncommunicable diseases and injuries: Córdoba, Argentina; Fortaleza, Brazil; and Greater Manchester, United Kingdom of Great Britain and Northern Ireland. The Summit, co-hosted by Bloomberg Philanthropies, the World Health Organization (WHO), Vital Strategies, and the City of Paris, convened mayors and officials from 61 cities in the Partnership for Healthy Cities network to address pressing public health issues and share effective strategies for saving lives and building healthier communities at the local level.
“Noncommunicable diseases, including heart disease, cancer, and diabetes, and injuries are responsible for more than 80% of all deaths globally, but the good news is, they are preventable,” said Michael R. Bloomberg, founder of Bloomberg L.P. and Bloomberg Philanthropies, WHO Global Ambassador for Noncommunicable Diseases and Injuries, and 108th mayor of New York City. “Cities are leading the way in implementing policies that are protecting public health and saving lives. This year’s winning cities are proving that progress is possible with strong leadership and political will, and we look forward to seeing the results of their efforts.”
The recipients of the 2025 Partnership for Healthy Cities Awards were chosen because they have made demonstrable progress in preventing noncommunicable diseases and injuries, setting an example that can be replicated in other jurisdictions.
All three winning cities are part of the Partnership’s Policy Accelerator, which provides training and support for drafting policies and establishing the political strategies needed to develop and enact them. These cities are working with the Partnership to improve public health in the following ways:
“Cities are at the forefront of the fight against noncommunicable diseases and injuries. The progress made in Córdoba, Fortaleza, and Greater Manchester is not only improving health today but also setting a model for others to follow," said WHO Director-General Dr Tedros Adhanom Ghebreyesus. "WHO is committed to working with cities to build healthier, safer and more resilient communities for all.”
“Local leadership has emerged as a powerful force for addressing the complex challenges presented by noncommunicable diseases and injuries,” said Dr Mary-Ann Etiebet, President and CEO, Vital Strategies. “We applaud the work of city leaders around the globe in their efforts to create healthier, safer environments for their populations. Their efforts are having a significant impact on people’s lives and well-being, while also demonstrating to national governments that there is significant support for these policy solutions.”
Launched in 2017, the Partnership for Healthy Cities is a global network of 74 cities working to prevent noncommunicable diseases and injuries. Supported by Bloomberg Philanthropies, in partnership with the World Health Organization and Vital Strategies, this initiative empowers cities worldwide to implement high-impact policy or programmatic interventions to reduce noncommunicable diseases and injuries in their communities. Through this network, city leaders are enacting transformative measures to improve the health of 300 million people across the globe.
The mayors participating in the Partnership for Healthy Cities Summit include:
About Bloomberg Philanthropies
Bloomberg Philanthropies invests in 700 cities and 150 countries around the world to ensure better, longer lives for the greatest number of people. The organization focuses on creating lasting change in five key areas: the arts, education, environment, government innovation, and public health. Bloomberg Philanthropies encompasses all of Michael R. Bloomberg’s giving, including his foundation, corporate, and personal philanthropy as well as Bloomberg Associates, a philanthropic consultancy that advises cities around the world. In 2024, Bloomberg Philanthropies distributed US$ 3.7 billion. For more information, please visit bloomberg.org, sign up for ournewsletter, or follow us onInstagram,LinkedIn,YouTube,Threads,Facebook, and X.
About the World Health Organization
Dedicated to the well-being of all people and guided by science, the World Health Organization leads and champions global efforts to give everyone, everywhere an equal chance at a safe and healthy life. We are the UN agency for health that connects nations, partners and people on the front lines in 150+ locations – leading the world’s response to health emergencies, preventing disease, addressing the root causes of health issues and expanding access to medicines and health care. Our mission is to promote health, keep the world safe and serve the vulnerable. For more information, visit www.who.int and follow WHO on Twitter, Facebook, Instagram, LinkedIn, TikTok, Pinterest, YouTube.
About Vital Strategies
Vital Strategies believes every person should be protected by an equitable and effective public health system. We partner with governments, communities and organizations around the world to reimagine public health so that health is supported in all the places we live, work and play. The result is millions of people living longer, healthier lives. To find out more, please visit www.vitalstrategies.org or follow us on LinkedIn.
Media Contacts
Veronica Lewin, Bloomberg Philanthropies, veronical@bloomberg.org
Erin Pallotta, Allison Worldwide, bloomberghealth@allisonworldwide.com
Jaimie Guerra, World Health Organization, guerraja@who.int
Christina Honeysett, Vital Strategies, choneysett@vitalstrategies.org
Following recommendations by the World Health Organization (WHO), the United Nations Commission on Narcotic Drugs (CND) has decided to place five new psychoactive substances and one medicine under international control.
The recommendations were developed by WHO Expert Committee on Drug Dependence--ECDD, which consists of global experts analyzing health risks and benefits of psychoactive substances circulating on global markets and alerting to include them under international control if evidence found that their use can cause harm for population health in countries.
“These substances have been brought to WHO’s attention for being clandestinely manufactured, posing serious risk to public health and society without any recognized therapeutic use,” said Dr Deus Mubangizi, WHO Director for Health Product Policy and Standards. “We are pleased that the Commission (on Narcotic Drugs) has accepted the full set of WHO recommendations and added these substances to relevant schedules in the 1961 or 1971 Conventions. We hope countries and communities will increase vigilance and take necessary actions to protect vulnerable groups particularly youth from these substances.”
Four substances placed in Schedule I of the Single Convention on Narcotic Drugs (1961), as amended by the 1972 Protocol are:
Substance placed in Schedule II of the Convention on Psychotropic Substances (1971):
Substance placed in Schedule IV of the Convention on Psychotropic Substances (1971):
WHO has been convening the ECDD as a scientific advisory body for over 70 years with the mission to protect populations from harmful substances and to ensure that psychoactive substances are available where needed for medical and scientific purposes. The ECDD conducts scientific reviews at the request of the UN Commission on Narcotic Drugs and is the only treaty-mandated body to provide health recommendations to the Commission to inform decisions in drug policy.
With the ongoing emergence of more harmful substances, including clandestinely manufactured synthetic opioids with no medical use such as fentanyl and nitazenes, Member States expressed interest in more scientific reviews of these substances by WHO in the coming period. Above-mentioned decisions were announced at the 68th regular session of the Commission on Narcotic Drugs, taking place in Vienna, Austria, on 10-14 March 2025.
The World Health Organization (WHO) today designated the Digital Ethics Centre at Delft University of Technology in the Netherlands as a WHO Collaborating Centre on artificial intelligence (AI) for health governance.
AI has the potential to re-shape health care, save lives and improve health and well-being. However, harnessing its benefits for good requires collaboration from stakeholders committed to robust governance, ethical safeguards, and evidence-based policies.
The WHO Collaborating Centre designation recognizes the Digital Ethics Centre at Delft University of Technology's decades-long history of cutting-edge research on responsible innovation, and its leadership in incorporating ethical values into design requirements for digital technologies. This inauguration marks the continuation of a strong partnership between the Digital Ethics Centre and WHO with the two entities jointly organizing international consultations, workshops, and the development of normative guidance and training in the past.
“WHO is committed to helping Member States plan, govern, and adopt responsible AI technologies,” said Dr Alain Labrique, Director of Digital Health and Innovation at WHO. “We are witnessing remarkable progress, with AI poised to transform health systems and support individuals on their health journeys. To ensure these benefits reach everyone ethically, safely, and equitably, we rely on strong technical and academic partnerships that guide us in this rapidly evolving field.”
The Collaborating Centre on AI for health governance will be instrumental in WHO’s efforts to ensure the ethical and responsible use of AI for health by advancing research on priority topics and providing expert input for WHO’s guidance development and policy-making. The Centre will serve as a hub for education and advocacy for science-driven research and facilitate knowledge-sharing and training through regional and country-level workshops.
“The fruit of two decades of research in digital ethics and responsible innovation, the Delft Digital Ethics Centre is one of the frontrunners in operationalizing ethical values into design requirements for digital technologies such as artificial intelligence," Professor Jeroen van den Hoven, Scientific Director at Delft Digital Ethics Centre noted. "We look forward to contributing to the global health community and advancing the responsible use of AI in health."
The Responsible and Ethical AI for Healthcare Lab, a collaboration between Delft University of Technology and its partners, will provide valuable insight into the challenges involved in the successful implementation of WHO guidance in clinical practice. "The designation of the Digital Ethics Centre at Delft University of Technology as a WHO Collaborating Centre strengthens our collective ability to ensure AI serves public health equitably and responsibly. This collaboration will play a critical role in supporting Member States to navigate the opportunities and challenges of AI, fostering trust, transparency, and innovation in digital health,” said Dr David Novillo-Ortiz, Regional Adviser and Unit Head for Data, Evidence and Digital Health at WHO’s Regional Office for Europe.
The Collaborating Centre on AI for health emphasizes WHO’s dedication to evidence-based AI governance, promoting its responsible use while upholding the highest ethical standards.